康新江
聊城大学 生命科学学院
地址：山东省聊城市湖南路1号 邮编：252001
手机：17753380586/15275662686
邮箱：kxj335@163.com
一、学习经历：
1995.9-2000.7 济宁医学院 预防医学 学士
2001.9-2004.7 华中科技大学同济医学院 公共卫生 硕士
2009.9-2014.7 北京大学 生理学 博士
二、工作经历：
2004.7-2009.9 聊城大学 助教/讲师
2014.7-2015.6 北京大学 科研助理
2015.6- 聊城大学 副教授
三、研究方向：
聚焦于多巴胺分泌异常导致的神经精神疾病发病机制研究、帕金森病的发病机制及治疗等研究。发表SCI论文18篇，累积影响因子~ 134，累积被引用210余次。其中自2014年以来，以第一/通讯作者在国际权威学术期刊（SCI）发表研究论文共计7篇，累计影响因子~ 50，累积被引用100余次。2020年，以第二作者在 Nature 发表学术论文“Reversing a model of Parkinson’s disease with in situ converted nigral neurons”。在帕金森病治疗研究方面，将干细胞移植到帕金森病大鼠模型纹状体中，改善了帕金森病大鼠模型的运动症状，为干细胞治疗帕金森病提供了理论基础，以‘Weekly press tipsheet’特别推荐论文形式发表（ PNAS，2014 ）。并进一步通过将中脑胶质细胞原位转化为DA神经元有效改善帕金森病的运动症状（ Nature，2020 ），文章一经发表，引起全世界的关注和热烈报道，为帕金森病的治愈提供了概念验证。在帕金森病致病机理研究方面，发现Syt11介导parkin功能异常导致的帕金森病，解决了长期以来悬而未决的parkin导致帕金森病的致病机理（ Nature communications，2018 ）。发现了多巴胺（DA）分泌调控的新通路及吸烟成瘾的新机制（ Nature communications ，2014）。由于在囊泡循环和细胞分泌研究中的重要贡献，受邀撰写胞吐-胞吞偶联平衡机制方面的综述文章（ Frontiers in Molecular Neuroscience , 2017. Frontiers in Neuroscience , 2019. Neuroscientist, 2020）。
四、代表性论文：
1.Kang XJ#, Xu HD#, Teng SS#, Zhang XY, Deng ZJ, Zhou L, Zuo PL, Liu B, Liu B, Wu QH, Wang L, Hu MQ, Dou HQ, Liu W, Zhu FP, Li Q, Guo S, Gu JL, Lei Q, Lü J, Mu Y, Jin M, Wang SR, Jiang W, Liu K, Wang CH, Li WL, Zhang K, Zhou Z. Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15804-9. doi: 10.1073/pnas.1408484111. Epub 2014 Oct 20. （IF: 9.81，#Co-first authors）
2.Qian H, Kang XJ, Hu J, Zhang DY, Liang ZY, Meng F, Zhang X, Xue YC, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature. 2020 Jun 24. 582:550–556.（IF：42.5）
3.Wang CH#, Kang XJ#, Zhou L#, Chai ZY, Wu QH, Huang R, Xu HD, Hu MQ, Sun XX, Sun SH, Li J, Jiao RY, Zuo PL, Zheng LH, Yue ZY, Zhou Z. (2017) Synaptotagmin-11 is a critical mediator of parkin linked neurotoxicity and Parkinson’s Disease-like pathology. Nat. Commun. 2018 Jan 8;9(1):81. doi: 10.1038/s41467-017-02593-y. （IF: 12.35, #Co-first authors）
4.Wang L#, Shang SJ#, Kang XJ#, Teng SS, Zhu FP, Liu B, Wu QH, Li ML, Liu W, Xu HD, Zhou L, Jiao RY, Dou HQ, Zuo PL, Zhang XY, Zheng LH, Wang SR, Wang CH and Zhou Z (2014) Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine. Nat. Commun. 2014 May 21;5:3925. doi: 10.1038/ncomms4925.（IF: 11. 47, #Co-first authors）
5.Huang MZ, Wang BB, Li XP, Fu CL*, Wang CH*, Kang XJ*. alpha-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling. Front Neurosci. 2019 Jan 28;13:28. doi: 10.3389/fnins.2019.00028. eCollection 2019.（IF: 3.88, *Corresponding authors）
6.Wu XA, Hu SQ, Kang XJ*, Wang CH*. Synaptotagmins: beyond presynaptic neurotransmitter release. Neuroscientist. 2019 May 3:1073858419844497. doi: 10.1177/1073858419844497. （IF: 7.46, *Corresponding authors）
7.Xie ZL, Long JG, Liu JK, Chai ZY*, Kang XJ*, Wang CH*. (2017) Molecular mechanisms for the coupling of endocytosis to exocytosis in neurons. Frontiers in Molecular Neuroscience. 10:47. doi:10.3389/fnmol.2017.00047. （IF: 5.2, *Corresponding authors）
8.Xu HD, Wang SR, Zuo PL, Zhou L, Sun XX, Hu MQ, Liu B, Wu QH, Dou HQ, Liu B, Zhu FP, Teng SS, Zhang X, Wang L, Li Q, Jin M, Kang XJ*, Xiong W, Wang CH*, Zhou Z* (2015) Striatal dopamine release in a schizophrenia mouse model measured by electrochemical amperometry in vivo. Analyst, 2015 Feb 5.（IF: 4.11, *Corresponding authors）
五、其他论文：
1.Zhang QF, Liu B, Wu QH, Liu B, Li YL, Sun SH, Wang Y, Wu X, Chai ZY, Jiang XH, Liu XY, Hu MQ, Wang YS, Yang YT, Wang L, Kang XJ, Xiong YF, Zhou Y, Chen XK, Zheng LH, Zhang B, Wang CH, Zhu FP, Zhou Z. Differential Co-release of Two Neurotransmitters from a Vesicle Fusion Pore in Mammalian Adrenal Chromaffin Cells. Neuron. 2019 Apr 3;102(1):173-183.e4. doi: 10.1016/j.neuron.2019.01.031. Epub 2019 Feb 14.
2.Dou HQ, Wang CH, Wu X, Yao LJ, Zhang XY, Teng SS, Xu HD, Liu B, Wu QH, Zhang QF, Hu MQ, Wang YS, Wang L, Wu Y, Shang SJ, Kang XJ, Zheng LH, Zhang J, Raoux M, Lang J, Li Q, Su J, Yu X, Chen LY and Zhou Z (2014) Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia, 2015 Feb;58(2):324-33. doi: 10.1007/s00125-014-3437-z. Epub 2014 Nov 9.
3.Song Q, Huang M, Wang B, Kang X, Wang C. Bidirectional regulation of Ca2+ in exo-endocytosis coupling. Sci China Life Sci. 2018 Dec;61(12):1583-1585. doi: 10.1007/s11427-018-9429-6. Epub 2018 Nov 26.
4.Wang L, Zhang XY, Xu HD, Zhou L, Jiao RY, Liu W, Zhu FP, Kang XJ, Liu B, Teng SS, Wu QH, Li ML, Dou HQ, Wang CH, Zuo PL, Wang SR and Zhou Z (2014) Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice. Journal of Physiology, 592:3559–3576.
5.Liu LN, Zhu FP, Song MY, Kang XJ, Shang SJ, Zhang XY, Xu HD, Teng SS, Liu B, Kuo ST, Liu W, Li ML, Zhou L, Jiao RY, Wang CH, Wang SR, Yang H, Zhang B, Zhou Z, Xu ZQ.（2014）Effect of cocaine on ion channels and glutamatergic EPSCs in noradrenergic locus coeruleus neurons. J Mol Neurosci. Jul;53(3):345-51
6.Shang SJ, Wang CH, Liu B, Wu QH, Zhang QF, Liu W, Zheng LH, Xu HD, Kang XJ, Zhang XY, Wang YS, Zheng H, Wang SR, Xiong W, Liu T, Zhou Z (2014) Extracellular Ca2+ per se inhibits quantal size of catecholamine release in adrenal slice chromaffin cells. Cell Calcium, 56:202–207.
7.Kuo ST, Wu QH, Liu B, Xie ZL, Wu X, Shang SJ, Zhang XY, Kang XJ, Liu LN, Zhu FP, Wang YS, Hu MQ, Xu HD, Zhou L, Liu B, Chai ZY, Zhang QF, Liu W, Teng SS, Wang CH, Guo N, Dou HQ, Zuo PL1, Zheng LH, Zhang CX1, Zhu DS, Wang L, Wang SR, Zhou Z. (2013). Importing, caring, breeding, genotyping, and phenotyping a genetic mouse in a Chinese University. J Mol Neurosci, 53(3):487-92.
8.Zuo PL, Yao W, Sun L, Kuo ST, Li Q, Wang SR, Dou HQ, Xu HD, Zhang CX, Kang XJ, Zhou Z, Zhang B. Impulse-dependent extracellular resting dopamine concentration in rat striatum in vivo. Neurochem Int. 2012 Nov 15. pii: S0197-0186(12)00366-X
9.Guo N, Yao W, Wang SR, Zhu J, Huang D, Zuo PL, Kang XJ, Fu CL, Zhou Z, Zhang B. Nicotine dynamically modulates dopamine clearance in rat striatum in vivo. Neurochem Int. 2012 Mar;60(4):355-9.
10.Wang SR, Yao W, Huang HP, Zhang B, Zuo PL, Sun L, Dou HQ, Li Q, Kang XJ, Xu HD, Hu MQ, Jin M, Zhang L, Mu Y, Peng JY, Zhang CX, Ding JP, Li BM, Zhou Z. Role of vesicle pools in action potential pattern-dependent dopamine overflow in rat striatum in vivo. Journal of Neurochemistry. 2011 Oct;119(2):342-53.
